Chemistry

Camouflage has been used by military forces since the ancient Roman Empire. It seems obvious that matching the colour of your vehicle to the environment will make you a far less visible target. But using modern scientific techniques, cam...
Camouflage has been used by military forces since the ancient Roman Empire. It seems obvious that matching the colour of your vehicle to the environment will make you a far less visible target. But using modern scientific techniques, camouflage can be far more than simply painting a vehicle to blend into the background. Foxhound light patrol vehicle in Army Brown. Courtesy of AkzoNobel. AkzoNobel, a paints and coatings company based in the Netherlands, has announced a new paint for British Army vehicles that not only works as camouflage, but can help to protect soldiers against chemical attacks. British army vehicles have been painted with sand coloured camouflage since before the Second World War. Warfare has changed a lot since then, so it’s about time they were redecorated. To devise a new colour scheme, the Ministry of Defence collected samples of soil and rocks from Afghanistan, along with high resolution imagery. The new hue was given the, perhaps uninspiring, name of Army Brown. Army Brown is similar to the tan colour used by the US and Australian militaries, and designed to work well both in arid environments and amongst vegetation. Tasked with developing the paint, AkzoNobel decided to build in more functionality, and designed a water-based solution that would protect the vehicles from corrosion and is capable of absorbing chemical warfare agents. Thanks to the inclusion of a specific resin, the paint can also be peeled off and disposed of when contaminated or if a quick change of colour is required. The new paint has already been applied to Foxhound light patrol vehicles, as well as some of the Warrior tracked vehicles in use in Afghanistan. Further developments in the pipeline include a bespoke molecule which builds on the current generation’s ability to absorb chemical agents by changing colour to alert vehicle operators to their presence, and will also neutralise them on contact. This marks an evolution of the capabilities of camouflage, and should help to keep soldiers safer on the front line in some of the most challenging environments. Please indulge the author… Hello!  I’m Ben Valsler, the newest addition to the Chemistry World family. I’ve been given the newly created position of Online and Multimedia editor, so amongst other things I’ll regularly be contributing to this blog, as well as inviting posts from occasional guest bloggers. I must confess, I’m not a chemist. I’ve studied zoology & science communication, and throughout my career so far have concentrated on topics as diverse as genetics, astronomy & materials science. Being a jack of all trades (and some would say master of none) has given me a real interest in the boundaries – the edge effects where one specialism meets another, where theory meets application and where science meets engineering. That’s why this story caught my eye. What seems initially like a simple request – formulate a new paint of a certain colour – led to the development of a coating that can do so much more.
44 minutes ago
How much does Big Pharma spend on R&D, compared to what it takes in? This topic came up during a discussion here last week, when a recent article at The Atlantic referred to these expenditures as "only" 16 cents on the dollar, and I want...
How much does Big Pharma spend on R&D, compared to what it takes in? This topic came up during a discussion here last week, when a recent article at The Atlantic referred to these expenditures as "only" 16 cents on the dollar, and I wanted to return to it. One good source for such numbers is Booz, the huge consulting outfit, and their annual "Global Innovation 1000" survey. This is meant to be a comparison of companies that are actually trying to discover new products and bring them to market (as opposed to department stores, manufacturers of house-brand cat food, and other businesses whose operations consist of doing pretty much the same thing without much of an R&D budget). Even among these 1000 companies, the average R&D budget, as a per cent of sales, is between 1 and 1.5%, and has stayed in that range for years. Different industries naturally have different averages. The "chemicals and energy" category in the Booz survey spends between 1 and 3% of its sales on R&D. Aerospace and defense companies tend to spend between 3 and 6 per cent. The big auto makers tend to spend between 3 and 7% of their sales on research, but those sales figures are so large that they still account for a reasonable hunk (16%) of all R&D expenditures. That pie, though, has two very large slices representing electronics/computers/semiconductors and biopharma/medical devices/diagnostics. Those two groups account for half of all the industrial R&D spending in the world. And there are a lot of variations inside those industries as well. Apple, for example, spends only 2.2% of its sales on R&D, while Samsung and IBM come in around 6%. By comparison with another flagship high-tech sector, the internet-based companies, Amazon spends just over 6% itself, and Google is at a robust 13.6% of its sales. Microsoft is at 13% itself. The semiconductor companies are where the money really gets plowed back into the labs, though. Here's a roundup of 2011 spending, where you can see a company like Intel, with forty billion dollars of sales, still putting 17% of that back into R&D. And the smaller firms are (as you might expect) doing even more. AMD spends 22% of its sales on R&D, and Broadcom spends 28%. These are people who, like Alice's Red Queen, have to run as fast as they can if they even want to stay in the same place. Now we come to the drug industry. The first thing to note is that some of its biggest companies already have their spending set at Intel levels or above: Roche is over 19%, Merck is over 17%, and AstraZeneca is over 16%. The others are no slouches, either: Sanofi and GSK are above 14%, and Pfizer (with the biggest R&D spending drop of all the big pharma outfits, I should add) is at 13.5%. They, J&J, and Abbott drag the average down by only spending in the 11-to-14% range - I don't think that there's such a thing as a drug discovery company that spends in the single digits compared to revenue. If any of us tried to get away with Apple's R&D spending levels, we'd be eaten alive. All this adds up to a lot: if you take the top 20 biggest industrial R&D spenders in the world, eight of them are drug companies. No other industrial sector has that many on the list, and a number of companies just missed making it. Lilly, for one, spent 23% of revenues on R&D, and BMS spend 22%, as did Biogen. And those are the big companies. As with the chip makers, the smaller outfits have to push harder. Where I work, we spent about 50% of our revenues on R&D last year, and that's projected to go up. I think you'll find similar figures throughout biopharma. So you can see why I find it sort of puzzling that someone can complain about the drug industry as a whole "only" spending 16% of its revenues. Outside of semiconductors, nobody spends more
about 4 hours ago
Readers of my blog know that I am a promoter of Open Science and have been so for a very long time. One of the main reasons why I am, is that Open just is more efficient. No worry about getting formal approval to access something, faster...
Readers of my blog know that I am a promoter of Open Science and have been so for a very long time. One of the main reasons why I am, is that Open just is more efficient. No worry about getting formal approval to access something, faster exchange of knowledge, and people just doing their science. Situation #1 You published your paper and it is appealing to many people. They all start emailing you for a reprint and you end up spending an hour or two every week answering those emails and attaching the PDF to your replies. Situation #2 Not that you really have time for it, but don't you just wish you had time to print that really interesting paper to put it on your desk pile of papers to read? Well, no luck, your library had to cancel the subscription. And IBL is just a too expensive approach (and sometimes slow). Now, because the majority of my papers are Open Access, I never have Situation #1. In fact, I don't think anyone gets such emails a lot. (Please leave a comment if you get more than one such request in half a year.) Situation #2 is much more common, though with access to two university libraries, the journals must be really obscure for me not to have access. But there are additional options to solve Situation #2 before you make an author run into Situation #1. The upcoming solution to this (well, one of them, there are others) is using #icanhazpdf. Just use this hashtag on social media to let people know you really like to read that paper. The screenshot of a Twitter search shows some examples. This is definitely a faster mechanism to have access to reprint papers. Now, is this legal? No (unless one of the original authors replies by sending a reprint). Do I recommend it? No. See e.g. this post. Is #icanhazpdf part of Open Science? No. It is a symptom of the limitations in scalability of closed-access publishing. With so many people still dying of things that we are so close to curing, I believe scalability is of critical importance. Therefore, I rather solve this literature access issue by publishing in (true) Open Access journals. You should too; it really is not that expensive (e.g. comparable to one ACS visit and often cheaper). But #icanhazpdf is an interesting trend, one that I feel you should be aware of. And I blog this, because not everyone seems to know this alternative yet. BTW, another excellent alternative, particularly in The Netherlands. Visit a friend at another university in the afternoon/evening and spend the rest of the day in the library of the other university to copy (download) those interesting papers. The IBL systems will tell you exactly which journals the other university has. Slower, but comes with the advantage of giving you an excuse to visit your friends elsewhere.
about 6 hours ago
Annual Results: Latest fiscal year hurt nation’s chemical makers
Annual Results: Latest fiscal year hurt nation’s chemical makers
about 10 hours ago
Patterning method is inspired by how the environment shapes shells and coral
Patterning method is inspired by how the environment shapes shells and coral
about 10 hours ago
Accidents: Yearlong study aims for safer practices in nonindustry facilities
Accidents: Yearlong study aims for safer practices in nonindustry facilities
about 10 hours ago
Piled Higher & Deeper by Jorge Cham www.phdcomics.com title: "A Professor's Prayer" - originally published 5/17/2013 ...
Piled Higher & Deeper by Jorge Cham www.phdcomics.com title: "A Professor's Prayer" - originally published 5/17/2013 For the latest news in PHD Comics, CLICK HERE!
about 11 hours ago
Thermally stable ionic liquids prepared for the electrodeposition of metallic silver with high deposition rates
Thermally stable ionic liquids prepared for the electrodeposition of metallic silver with high deposition rates
about 13 hours ago
“May I present to you: the Smellmaster 9000.” One of my professors once told me quite categorically that if you can smell someone's chemistry, they are doing a bad job.  His point was that any chemist worth their salt would be doing sti...
“May I present to you: the Smellmaster 9000.” One of my professors once told me quite categorically that if you can smell someone's chemistry, they are doing a bad job.  His point was that any chemist worth their salt would be doing stinky things in properly-maintained fumehoods, and never exposing themselves or their colleagues to whatever unholy stenches their reagents possessed.  To a certain extent, I agree with him.   I've never had to brave the foul miasmas of things like isonitriles and I never plan to, but if that eventuality arises you can be sure that I'll do that in a fumehood.  Or possibly in a fumehood inside a fumehood. But for most people who work in chemistry labs, the occasional waft of bizarre odours is not unusual.  Sometimes it's even useful: a project I was doing a while back involved the consumption of phenylacetylene (which has quite a characteristic odour, somewhat similar to styrene), and doing a careful wafting test actually proved to be about as effective for determining a reaction's completion as a TLC.  Not that everyone should smell-test all their reactions!  But the point is that working as a chemist tends to give you the peculiar ability to identify reagents by their smell, simply through familiarity caused by repeated low-concentration exposure.  The sharp fruitiness of ethyl acetate, the almond sweetness of benzaldehyde, the bitter nose-wrinkling sting of pyridine…there's an entire world of pleasant and unpleasant smells in the world of organic chemistry, and just like everyone starts to accumulate their favourite and most-hated customers when working in retail, I have a suspicion that each chemist has their own personal list of best- and worst-smelling chemicals.  I'm sure we all remember high-school chemistry, and detecting the rancid butter stink of carboxylic acids down the hallway when people did their esterification lab, then getting to smell the artificial rum, banana, and mint flavours that resulted when they did the lab themselves. Smells form very strong memories, and I thought it might be nice to share some of my own memorable olfactory experiences in chemistry, and see what others had to add to the conversation. Note: I should emphasize that I did not go around shoving my nose in bottles of these chemicals, nor should you.  Please be careful with all chemistry you do, and always do it in a fumehood for your safety and that of your colleagues. 1. Pentafluorophenol.  I did some solution-phase peptide couplings a while back and had to weigh this stuff out on a regular basis.  Its physical properties leave something to be desired (so hygroscopic it appears to melt as you weigh it, highly volatile, and not exactly cheap), but its odour is something I don't think I will ever forget in my life.  It smells almost like some non-existent overripe fruit, almost cloying in its sweetness, lingering for quite some time after being capped and removed from the weighing area.  It's one of those smells that I wouldn't say I enjoy, but it's so intriguing that I also can't say that I dislike it, either. 2.  Chloroacetyl chloride.  I love the smell of vinegar to begin with, but this stuff takes it to a whole other level.  Doing carbohydrate chemistry introduced me to this molecule and though I haven't smelled it since it's another absolutely unforgettable one.  It has a very similar smell to regular old acetic acid, but with this sort of appalling greasiness to it that I always found interesting and somewhat appealing.  Similar to this is trufluoroacetic acid, but not only is TFA more dangerous, its odour is so sharp at even low concentrations that it is on the whole quite unpleasant. 3. Methylindoles.  Very recently I had the regrettable task of doing some indole chemistry, and I am glad to have it behind me.  Though definitely not anywhere near the top of the all-time worst chemical smells, there is something about N-methyl, 1,3-dimethyl, and especially 2-methylindole that I cannot stand
about 16 hours ago
Incorporating a fluorescent probe into a polymeric matrix gives a sensor array that can recognize eight different analytes
Incorporating a fluorescent probe into a polymeric matrix gives a sensor array that can recognize eight different analytes
1 day ago