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Research Integrity: Former GlaxoSmithKline R&D leader in China claims data mixup was inadvertent
Research Integrity: Former GlaxoSmithKline R&D leader in China claims data mixup was inadvertent
about 2 hours ago
Piled Higher & Deeper by Jorge Cham www.phdcomics.com title: "The origin of the name" - originally published 6/17/2013 ...
Piled Higher & Deeper by Jorge Cham www.phdcomics.com title: "The origin of the name" - originally published 6/17/2013 For the latest news in PHD Comics, CLICK HERE!
about 3 hours ago
Neurochemistry: Compound could help researchers study an important class of potassium channels and develop new epilepsy therapies
Neurochemistry: Compound could help researchers study an important class of potassium channels and develop new epilepsy therapies
about 4 hours ago
Natural products come up around here fairly often, as sources of chemical diversity and inspiration. Here's a paper that combines them with another topic (epigenetics) that's been popular around here as well, even if there's some disagre...
Natural products come up around here fairly often, as sources of chemical diversity and inspiration. Here's a paper that combines them with another topic (epigenetics) that's been popular around here as well, even if there's some disagreement about what the word means. A group of Japanese researchers were looking at the natural products derived from a fungus (Chaetomium indicum). Recent work has suggested that fungi have a lot more genes/enzymes available to make such things than are commonly expressed, so in this work, the team fed the fungus an HDAC inhibitor to kick its expression profile around a bit. The paper has a few references to other examples of this technique, and it worked again here - they got a significantly larger amount of polyketide products out of the fermentation, included several that had never been described before. There have been many attempts to rejigger the synthetic machinery in natural-product-producing organisms, ranging from changing their diet of starting materials, adding environmental stresses to their culture, all the way to manipulating their actual genomic sequences directly. This method has the advantage of being easier than most, and the number of potential gene-expression-changing compounds is large. Histone deacetylase inhibitors alone have wide ranges of selectivity against members of the class, and then you have the reverse mechanism (histone actyltranferase), methyltransferase and demethylase inhibitors, and many more. These should be sufficient to produce weirdo compounds a-plenty.
about 6 hours ago
IN GREEK mythology the firmament was held aloft by a titan, one of a race of deities descended from Earth and sky. So it is fitting that the Milky Way 2, or Tianhe-2 in Chinese, surpassed an American machine called Titan to become the wo...
IN GREEK mythology the firmament was held aloft by a titan, one of a race of deities descended from Earth and sky. So it is fitting that the Milky Way 2, or Tianhe-2 in Chinese, surpassed an American machine called Titan to become the world' fastest supercomputer, according to a twice-yearly list published on June 17th by TOP500, an outfit which keeps score in such matters.Today's supercomputers are kept busy with tasks less gruelling than preventing the sky from falling. They do, though, stop buildings and aeroplanes from suffering the fate, as well as helping predict weather, model various other physical phenomena, search for oil or gas reserves, encrypt and decrypt communications and simulate all manner of processes. Their speed, meanwhile, serves as a proxy for their home country's technological prowess.Which is why not just geeks eagerly await TOP500's rulings. China was widely expected to reclaim the crown it first won in 2010 with Tianhe-1 but which it lost just six months later to Japan's Riken. At 33.86 trillion floating-point operations per second (or 34 petaflops, in the jargon), Tianhe-2 is nearly ten times faster than its older sibling, and almost twice as fast as the second-placed Titan, which sits in Oak Ridge National Laboratory, in Tennessee.Tianhe-2, rumoured to cost $100m, is composed of what looks like 170 large refrigirators and occupies 720 square metres. At top speed, it consumes almost 18MW of power, enough to sustain several thousands households, more than twice as much as Titan does (though it occupies 15% less volume).The Middle Kingdom may have pipped America to the top spot this time round, but in other respects it still lags behind. For one thing, it only has only one other machine in the top ten. The United States, by contrast, has five. It is also home to more than half of the world's top 500 supercomputers, compared with China's 66.And, making the mythological analogy even more apposite, much of Tianhe-2's gubbins, including many of its processors, come from Titan's homeland. Only one in eight of its 3.2m processing cores is "made in China", according to Jack Dongarra, an editor of TOP500, though that is a vast improvement from Tianhe-1, which carried no Chinese processors. Titan and its ilk may stand beneath the Milky Way. But without them, it seems, Tianhe would collapse. Follow paywall rules
about 6 hours ago
The below slides are part of the introduction for the hands on for the #MIILS2013 course this afternoon. I had the participants look at creating RDF the hard way: using Bioclipse script (using this Bioclipse-OpenTox version). And, they h...
The below slides are part of the introduction for the hands on for the #MIILS2013 course this afternoon. I had the participants look at creating RDF the hard way: using Bioclipse script (using this Bioclipse-OpenTox version). And, they had to follow the Open PHACTS RDF Guidelines, VoID specification, etc. #MIILS2013 Practical: Bioclipse for RDF minting from Egon Willighagen
about 7 hours ago
From the inbox:Job Description: The Australian Synchrotron is seeking highly motivated research scientists driven by the opportunity to engage and collaborate with industry to deliver scientific outcomes in the role of Industry Support S...
From the inbox:Job Description: The Australian Synchrotron is seeking highly motivated research scientists driven by the opportunity to engage and collaborate with industry to deliver scientific outcomes in the role of Industry Support Scientists. Industry Support Scientists will play a key role in the development of partnerships and support of commercial and non-commercial users in experiment design and the effective application of the Australian Synchrotron beamline facilities. In addition, the roles will provide post-experiment support to users including the analysis of data and the writing of commercial reports. There exist 3 vacancies for Industry Support Scientists in the following key areas: Industry Support Scientist - Spectroscopy: Infra-red spectroscopy/microscopy experimentation and analysis. X-ray fluorescence, XANES and EXAFS experimentation and analysisIndustry Support Scientist - Biological Diffraction: Protein crystallography, experimentation and analysis. Small Angle X-ray Scattering from macromolecules, experimentation and analysisIndustry Support Scientist - Materials Diffraction and Scattering: Powder diffraction experimentation with whole pattern fitting (Rietveld) analysis for quantitative analysis and/or structure solution. Single crystal diffraction experimentation and analysis for small molecule structure determination. Small Angle X-ray Scattering (SAXS) from solutions or solids, experimentation and analysis. Best wishes -- click here to apply. (Nice salary! starting at $75k US.)
about 7 hours ago
Good morning! Between June 13 and June 17, 56 new positions were posted on the C&EN Jobs website. Of these, 8 (14%) are academically connected and 39 (70%) are from Kelly Scientific Resources.Thousand Oaks, CA: Amgen is searching for a B...
Good morning! Between June 13 and June 17, 56 new positions were posted on the C&EN Jobs website. Of these, 8 (14%) are academically connected and 39 (70%) are from Kelly Scientific Resources.Thousand Oaks, CA: Amgen is searching for a B.S./M.S. associate to work on the molecular modeling team:Amgen is seeking a highly qualified individual to provide scientific computing and decision support in the area of chemical and biological informatics. As a member of the molecular modeling team, the individual will have responsibilities in the following areas: 1) scientific computing, including implementing and developing cutting edge scientific advances; 2) scientific data analysis and decision support, including applying scientific computing techniques to maintain the existing infrastructures as well as develop new capabilities.3-5 years "scientific experience" desired.Hoboken, NJ: Wiley is searching for a sales associate for their chemistry databases. Wiley has chemistry databases?Tulsa, OK: A staffing agency is looking for a high school diploma holder or B.S. chemist to be a lab tech for an olefin polymerization lab. In the right circumstances, this would be a great position to get some oil/gas/polymer experience -- hopefully for a little more than $16-$18/hour, though. (Unknown how good that is in Tulsa.)Emeryville, CA: Sandia National Laboratories desires a Ph.D. computational biologist/chemist for a postdoctoral position to work on biomass research. Bet they pay well (I hope.)Who are you?: Can anyone tell me who this "sales technical consultant" position is with? (NY/NJ area)
about 7 hours ago
Good morning! Between June 11 and June 17, there were 10 academic positions posted on the C&EN Jobs website. The numbers:Total number of ads: 10- Postdocs: 0- Tenure-track faculty: 4- Temporary faculty: 2- Lecturer positions: 3- Staff ...
Good morning! Between June 11 and June 17, there were 10 academic positions posted on the C&EN Jobs website. The numbers:Total number of ads: 10- Postdocs: 0- Tenure-track faculty: 4- Temporary faculty: 2- Lecturer positions: 3- Staff positions: 1- US/non-US: 7/3Evanston, IL: Northwestern University is searching for a Ph.D. NMR spectroscopist to run their walkup NMR facility.Lubbock, TX: Texas Tech University is looking for a general/organic chemistry laboratory coordinator. Ph.D. desired.Quebec City, Quebec: Université Laval is searching for an organic/bioorganic assistant professor. Quebec City is pretty lovely, really.Okanagan, British Columbia: The University of British Columbia - Okanagan campus is looking for a head of chemistry, looks like. It's like Canadian week!Austin, TX: St. Edward's University is hiring a visiting assistant professor of chemistry. Organic Ph.D. desired, will consider physical/analytical chemists.Hmmm: I think Queen's University - Belfast is having problems with the C&EN Jobs software, having posted their position for Ph.D. studentships 3 times.
about 8 hours ago
Good morning! Between June 11 and June 17, there were 10 academic positions posted on the C&EN Jobs website. The numbers:Total number of ads: 10- Postdocs: 0- Tenure-track faculty: 4- Temporary faculty: 2- Lecturer positions: 3- Staff ...
Good morning! Between June 11 and June 17, there were 10 academic positions posted on the C&EN Jobs website. The numbers:Total number of ads: 10- Postdocs: 0- Tenure-track faculty: 4- Temporary faculty: 2- Lecturer positions: 3- Staff positions: 1- US/non-US: 7/3Evanston, IL: Northwestern University is searching for a Ph.D. NMR spectroscopist to run their walkup NMR facility.Lubbock, TX: Texas Tech University is looking for a general/organic chemistry laboratory coordinator. Ph.D. desired.Quebec City, Quebec: Université Laval is searching for an organic/bioorganic assistant professor. Quebec City is pretty lovely, really.Okanagan, British Columbia: The University of British Columbia - Okanagan campus is looking for a head of chemistry, looks like. It's like Canadian week!Austin, TX: St. Edward's University is hiring a visiting assistant professor of chemistry. Organic Ph.D. desired, will consider physical/analytical chemists.Hmmm: I think Queen's University - Belfast is having problems with the C&EN Jobs software, having posted their position for Ph.D. studentships 3 times.
about 8 hours ago