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Takeda and Seattle Genetics Highlight Post-Hoc Analysis Examining Progression-free Survival with ADCETRIS ® (brentuximab vedotin) Versus Prior Therapy at the International Conference on Malignant Lymphoma ? Analysis showed more than 60 percent of patients achieved longer progression-free survival following treatment with ADCETRIS compared to prior therapy ? LUGANO, Switzerland--(BUSINESS WIRE)-- Takeda Pharmaceutical Company Limited (TSE:4502) and Seattle Genetics, Inc. (NAS: SGEN) today announced data from a post-hoc analysis examining progression-free survival (PFS) following treatment with ADCETRIS® (brentuximab vedotin) versus last prior therapy in patients diagnosed with relapsed or refractory Hodgkin lymphoma (HL) post-autologous stem cell transplant (ASCT) or relapsed or refractory systemic anaplastic large cell lymphoma (sALCL). The data were highlighted during a presentation at the 12th International Conference on Malignant Lymphoma (ICML) being held June 19-22, 2013 in Lugano, Switzerland. ADCETRIS is an antibody-drug conjugate (ADC) directed to CD30, a defining marker of classical HL and sALCL. The post-hoc analysis compared investigator assessed PFS following ADCETRIS single-agent treatment to the last prior systemic therapy in patients taking part in two pivotal Phase 2 studies. The post-hoc analysis was conducted in patients with relapsed or refractory HL post-ASCT or relapsed or refractory sALCL in the intent-to-treat (ITT) population. It also included prior systemic treatment histories and post-ADCETRIS stem cell transplant experience for each patient in the ITT populations. "These encouraging data suggest that ADCETRIS may delay disease progression compared to prior therapies used in this heavily pretreated patient population," said John Radford, M.D., Professor of Medical Oncology, University of Manchester, Manchester, UK. "ADCETRIS is a CD30-targeted treatment option for patients with relapsed or refractory HL or relapsed or refractory sALCL that has shown a high overall response rate, including durable complete responses in both of its approved indications." Progression-free survival analyses of two pivotal phase 2 studies of brentuximab vedotin in patients with relapsed or refractory Hodgkin lymphoma or systemic anaplastic large-cell lymphoma (Poster #303) The analysis, presented by Dr. Radford, included: Relapsed or Refractory HL post-ASCT 102 patients (median age 31 years) diagnosed with relapsed or refractory HL post-ASCT received a median of 3.5 (range, 1-13) prior chemotherapy regimens, not including ASCT, prior to enrollment in the study 91 percent of patients received doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) as front-line therapyApproximately one-half of patients received ifosfamide, carboplatin, etoposide (ICE) as second-line therapyThere was no discernible pattern in terms of treatment regimens after second-line therapyAs expected this was a very heavily pretreated population prior to study entry 62 percent of patients achieved a longer PFS with ADCETRIS than with their last prior therapy at a median follow-up of 27 months Median PFS was 9.3 months (range, 1.2-36.4) with ADCETRIS versus 6.1 months (range, 1.0-110.2) with last prior therapy 63 percent of patients who relapsed within six months of their most recent ASCT and 65 percent of patients who relapsed within twelve months of their most recent ASCT achieved a longer PFS with ADCETRIS than with their last prior systemic therapy 20 patients underwent a stem cell transplant (STC) after receiving ADCETRIS, including: ASCT (1 patient), allogeneic SCT (18 patients), ASCT followed by allogeneic SCT (1 patient) 7 patients received a transplant after treatment with ADCETRIS alone Relapsed or Refractory sALCL 58 patients (media

All-Stars don't star all that much ... Erasmo is OK in the Rockies ... etc.

We all know the Jacksonville Jaguars are installing a new defensive system with head coach Gus Bradley, similar to the system he ran while with the Seattle Seahawks. Not only is the team digesting a new system, but defense could have as many as seven new starters on the defensive side entering the 2013 season. It generally takes time for a team to take in a new system and buy what the coach is selling, but veteran cornerback Marcus Trufant, who played under Bradley, thinks they're headed the right direction. "It’s still a process, but I think we’re ahead of the curve," Trufant told John Oehser of Jaguars.com. "I think everybody appreciates Gus as a person, as a coach – just the way he is, the joy and enthusiasm he brings to the game. I think everybody’s buys in. You know you’re going to get the same thing from Gus, good or bad. It’s good to know the coach has your back." Bradley has installed nearly the whole defensive scheme through OTA practices and Trufant says they're headed the right direction. "We’ve pretty much put in the whole book, just so we can get a look at it, Trufant told Oehser. "There’s going to be a learning curve, but we’re right on track." Keep reading: • Jaguars Film Room: Stopping the run with the Cover-3 • Things to watch in Jaguars training camp • Is Mike Kafka in the Jaguars QB mix? • The Jaguars are fine taking 5 QBs to training camp

The low number comes via the Gallup poll, which says exactly 23 percent of Americans think newspapers are worth trusting. But newspapers don't stand alone. Confidence in television news has also been slipping — it's tied with newspapers this year at 23 percent, which is slightly up from last year's all-time low of 21 percent. Newspapers and television news rank near the bottom of a list of 16 "societal institutions," according to the report. The only institutions television news and newspapers beat out this year are big business, organized labor, health maintenance organizations and Congress. Americans expressed the most confidence in the military, at 76 percent, and small businesses, at 65 percent. Well. We can't exactly recreate this poll here on Slog, but we can ask the question this way: [ Comment on this story ] [ Subscribe to the comments on this story ]

Alice In Chains: Seattle legends Our Amit caught up with Alice In Chains at Download and found the lads in pretty damn good spirits. Which is nice. Download 2014 will take place 13-15 June, with 5,000 tickets going on sale from June 21-July 1 at a special Early Bird deal of £10 less than the current, 2013 prices for 5-day camping tickets, 3-day camping and weekend arena tickets. To get yours, head to www.downloadfestival.co.uk from 9am on June 21.

While we all realize the perfect NFL schedule is almost impossible to achieve, it’s hard to think that a league that is typically ahead of the curve doesn’t realize how much this year’s NFL schedule is slanted against the Bills and Falcons. To fully lay out all the schedule disadvantaged clubs that we profiled on the home page of Buffalobills.com, here’s the comprehensive list that we compiled in terms of the number of teams each club has to face coming more than a week of rest either via a Thursday night game the week prior or a bye week for 2013. Teams that play against 5 teams with extra rest Buffalo Teams that play against 4 teams with extra rest Atlanta Teams that play against 3 teams with extra rest Arizona, Carolina, NY Giants, Oakland, Philadelphia, Tampa Bay Teams that play against 2 teams with extra rest Chicago, Cleveland, Denver, Detroit, Houston, NY Jets, San Diego Teams that play one team with extra rest Baltimore, Cincinnati, Dallas, Green Bay, Indianapolis, Jacksonville, Miami, Minnesota, Pittsburgh, San Francisco, Seattle, St. Louis, Tennessee, Washington Teams that play no teams with extra rest Kansas City, New England and technically New Orleans (New Orleans plays Seattle off their bye week, but the Saints are coming off a Thursday night game that same week giving Seattle only three more days to prepare than New Orleans instead of a week) Teams whose bye weeks were nullified or compromised Buffalo, Houston, Indianapolis, Seattle – Houston and Indy have same bye week then play the following week. Buffalo’s bye compromised by Atlanta getting 10-day break same week due to Thursday night game. Same with Seattle prior to their aforementioned meeting with New Orleans.

Our first roundup features the story of a man who set off on a journey from Seattle to São Paulo with a football at his feetWelcome to the first of our weekly compilation articles, which will pick out our favourite writing, galleries and features from around the web. This page is an opportunity to celebrate the best online journalism from around the globe and we want to hear what you think of our choices.We would love you to contribute to this series by posting your own suggestions below the line. If you're a writer, editor or blogger, please share your own work in the comments section and we will feature the best articles every Wednesday.The article of the weekDribbling Man: by Robert Andrew Powell, for GrantlandRichard Swanson was an unemployed divorcé who had reached his early forties and needed a change of scene. He had lost his job, sold his apartment and his youngest son had turned 18. Swanson was free from the ties that bind men of his age.With little to hold him in Seattle, he set off on a journey. Swanson hoped that São Paulo would be his destination and that his own two feet would carry him there. He took a football for company, dribbling it along the side of the road as he trampled southwards to Brazil.Swanson did not reach São Paulo and will not be at the first game of the 2014 World Cup, as he had hoped. He did not even make it past the US border. He had planned to dribble his football through 11 countries, but was killed by a pickup truck while walking on the wrong side of the road in Oregon.Swanson only covered 270 miles of his route. He did not see Mexican desert, Costa Rican rainforest or Panamanian jungle, but he exhibited a beautiful and confusing innocence that caught the imagination of writer Robert Andrew Powell.The journalist has worked for the New York Times, Sports Illustrated and This American Life, but his account of Swanson's fated trip must rank as one of the most personal stories written by a sports journalist this year – or any year, for that matter.While most people felt sorry for Swanson or laughed at his seemingly pointless waste of life, Powell responded to his death like he had lost a friend. His reacted with deep empathy as he too had suffered a crisis of confidence and sought solace from the simple act of putting one foot in front of the other.When Powell's life came crashing in on him a few years ago, he rid himself of his belongings and set off for the isolation of Colorado. The writer took up running; he ran, and ran, and ran, until something inside him mended and he was ready to face the wider world again. Powell's two years away gave him the space he needed to close down the part of his life that needed to end.By focusing all his attention on his feet, he cleared his mind. Powell was transformed by his time out and he thinks that Swanson was trying to achieve something similar. His long walk to Brazil was a way of clearing out his life and starting over. He didn't make it to São Paulo and we will never know if he found the transformation Powell thinks he was seeking.But his story has inspired people. And so has Powell's telling of it.Other stories we like1) Footballers, award nights and after-dinner speaking: WSCAs a 13-year-old youth footballer Mark Sanderson was treated to a night in the company of former Southampton defender Jim Steele, who was the guest of honour at his team's end-of-season awards presentation in 1996. Steele seemed to enjoy telling some stories about the old days and showing off his FA Cup winners' medal, but he was not paid for the privilege (to the writer's knowledge). He missed a trick. Kevin Keegan can earn £8,000 a night for sharing his anecdotes, while Andy Gray picks up £6,000. Sanderson's trek through the world of after-dinner speaking will make you feel poor.2) My week with the North Korea hockey team: DeadspinLured by the chance of spending some time with the North Korea ice hockey team, Peter Cox went to Cape Town to watch them compete against Greece,

A lot of people on here post what the Blazers should do this offseason to address the bench, center, and also trading players so I decided to come up with one of my own that I believe would address all of this! First: Trades! - Involves POR, BOS, ORL, HOU! http://espn.go.com/nba/tradeMachine?tradeId=mx2w6oa PDX GETS: Aaron Brooks, Terrence Jones, Tobias Harris, Greg Smith, & Terrence Williams!BOS GETS: Nic Batum, Thomas RobinsonORL GETS: Jeff Green, Will Barton + Pick #10HOU GETS: Glen Davis, Victor Claver + Blazers 3 2nd Rds. PDX Verdict: Portland would do this because in Brooks we get a backup PG who cost the same as Maynor but he is also more proven and he played college ball at Oregon so im sure he wouldn't mind to come back! Also Terrence Jones is a SF/PF who can score, rebound, and play defense! He would probably be the 7th of 8th man. Terrence would like this because he is from Portland so it would be nice to reunite him here plus he is inexpensive but talented. Tobias Harris really came into his own when he got traded to Orlando and actually got a shot. Harris would fill the SF void that would be caused by Batum being traded. Also he is 10x cheaper than Batum and still young. Greg Smith is 6'11 250 lbs and 22 yrs old. This yr he averaged 16 mins with HOU while averaging 6 pts and 5 rbs. While also avg .6 blocks! Anyone who actually watched him play would agree he is a hell of a bargain for not even 800k a year! Smith could actually also fill our C void. He is a big body and plays good defense and can protect the rim. Terrence Williams is a SG/SF from Seattle who is versatile. Williams can score rebound and pass. Essentially Williams is lesser Batum who comes way cheaper. BOS Verdict: I believe boston would do this because Paul Pierce is getting older and they would be getting Batum to take over for him. Essentially they re-signed Green to take over Pierces void when he leaves but he is more of a PF than a SF. Also Batum has more potential and plays better defense while also being younger. Boston would also receive Thomas Robinson in this deal! Receiving T-Rob would be huge for BOS even though they drafted Sullinger due to the fact nobody knows how effective Sullinger will be because of his back issues. Also T-Rob is better than Sullinger I don't think that's questionable! ORL Verdict: Orlando receiving Green would be huge for their organization. With green barely signing a new contract he would be around for a while and could arguably be the new face of the organization. Also he is more proven than Tobias Harris so its a step up. Also he is versatile and can play the 3 and 4. Will Barton would be a nice piece for the Magic because he looked better than their backup 2's last year by a long shot! Super athletic and can score while grab boards. A bit raw but he will be good. Also they will receive the 10th pick from Portland to grab some more talent in the draft! I believe they would be ALL in for this. HOU Verdict: No arguing this.. Big Baby is a upgrade over everything they give up. Although it wouldn't clear up cap space for them to sign Dwight it would still be good for them because Glen is certainly capable of playing the PF and Asik at C would be a beast front court that is BIG! Plus they would get our 3 2nd round picks so if they REALLY wanted to get Dwight they could move the picks and Big baby to clear space. --------------------------------------------------------------------- If this were to happen Portland would clear up more cap space. Blazers in FA could sign Chris Copeland for fairly cheap and Jermaine O'Neal for cheap to! Portlands roster could look like... PG: Damian Lillard/Aaron Brooks/Eric MaynorSG: Terrence Williams/Wes Matthews/Elliot WilliamsSF: Tobias Harris/Chris Copeland/Terrence JonesPF: LaMarcus Aldridge/Terrence Jones/Jermaine O'Neal/Copeland?(Stretch 4)C: Greg Smith/Meyers Leonard/ Jermaine O'NealA lot of people on here post what the Blazers should do this offseason to address th

Tred Launches Its On-Demand Test Drive Service In Seattle by @ryanlawler

Tred, which hopes to provide a service that’s like “Uber for car test drives,” is finally launching its service to the public. The company, which hopes to streamline the process of buying a car by bringing on-demand test drives to your home or office, will first become available in Seattle. The service allows prospective car buyers to order a test drive for a flat fee, with the automobile of their choice being delivered to the location of their choice. Cars are brought to customers by Tred Auto Experts, who are trained to answer any questions about the car in question, and walk potential buyers through an hour-long evaluation and test drive. Cars are delivered for a flat fee of $19 a piece, and customers can have up to two delivered at a time. That gives them the ability to evaluate similar models of cars without having to visit multiple show rooms. Once the test drive is over, Tred’s Auto Experts leave users with a packet of resources to help walk them through the purchasing process. The idea is to not only make the process of evaluating cars more convenient and transparent, but to drastically reduce the cost and time associated with purchasing one. Customers spend an average of 11.5 hours shopping for cars at dealerships, according to Polk/Autotrader. And once they have made a decision, they typically spend more than 4 hours going through the process and paperwork of evaluating features and financing options before taking a car home. By giving car buyers the chance to evaluate the cars before heading to the showroom, as well as providing them with all the information they need before they’re ready to make a purchase, Tred eliminates a lot of the haggling and pressure that can turn car buyers off. It also reduces the amount of time that dealers spend processing paperwork and walking buyers through the purchasing process, freeing them up to help other showroom buyers. That’s one reason that local dealers have partnered with Tred in the Seattle area. The company has been working on those partnerships since it went through TechStars’ Seattle startup incubator last year. It’s also cleared to operate its on-demand test drives from the Washington State Association of Dealers of America and the Washington State Department of Licensing. While Seattle will be Tred’s first city, founder and CEO Grant Feek thinks the business model should work just as well in markets across the country. Unlike some other on-demand startup ideas, which rely on a certain density of population to work, Feek says he has faith that the idea will work in most markets, whether they’re urban or suburban. In fact, due to less need for a car, Tred might actually have less success in a large, densely populated city like New York. Tred has raised $1.8 million in seed funding from investors such as Fraser McCombs Capital, former Chairman and CEO of General Motors Rick Wagoner, Maveron Capital, Chris Sacca’s Lowercase Capital, Founder’s Co-Op, Great Oaks Venture Capital, and David Cohen.